Transdermal Cyclic Peptide cTDP is an award-winning, proprietary closed-loop peptide transdermal carrier developed by Mellgen Biotechnology. Its unique cyclic topology provides outstanding enzymatic stability and cell biocompatibility, selectively binding to cell membrane ion transport channels to reversibly open cutaneous absorption pathways within 5 minutes across follicular and intercellular routes.
This innovation completely overcomes the classical physical barrier of stratum corneum impermeability for biological macromolecules (recombinant proteins, peptides, polysaccharides, and nucleic acids), elevating transdermal absorption efficiency by over 10-fold. The process is gentle, fully reversible, and non-destructive to lipid bilayers, significantly enhancing active bioavailability and delivering remarkable firming and smoothing benefits.
Permeation Data
Franz diffusion cell transdermal permeation kinetics: cTDP stratum corneum absorption curve.
RAW MATERIAL TECHNICAL & REGULATORY DOSSIER
Comprehensive Technical, Quality Specification, and Regulatory Dossier for R&D Formulators, Procurement, and Product Managers
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Biotechnology Mechanism & Scientific Evidence
Authoritative Brochure Technical Diagram · Molecular Model · Transdermal & Efficacy Mechanism
Mechanism Diagram3rd-generation biological transdermal mechanism: cTDP targeting Na+/K+-ATPase to reversibly open follicular and paracellular pathways within 5 minutes, enhancing absorption 10-fold.
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Formulation R&D Engineer Guide (R&D Technical Dossier)
Formulation Application · Physicochemical Parameters · Stability & Compatibility
| INCI Name (CN) |
Decapeptide-4、三磷酸腺苷、1,2-1,2-Hexanediol, Aqua |
INCI Name (EN) |
Decapeptide-4, Adenosine Triphosphate, 1,2-Hexanediol, Aqua |
| CAS No. |
917094-11-2 / 987-65-5 / 6920-22-5 / 7732-18-5 |
Recommended Dosage |
0.2% - 2.0%（high 0.5% - 1.0%） |
| Optimal pH Range |
5.0 - 7.5 |
Thermal Processing |
Heat stable up to 80°C |
| Appearance & Odor |
Clear colorless liquid, odorless |
Solubility & Method |
Completely miscible with water |
💡 Compatibility Guidelines & Precautions: Broad compatibility across varied pH ranges, proteins, peptides, and botanical extracts
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Procurement & Compliance Dossier (Procurement & Compliance)
NMPA Code · MOQ · Sampling Support · Certificate of Analysis
| NMPA Submission Code |
✓ 211755-00075-4448 |
Supply Packaging |
1kg/fluorinated bottle, 5kg/drum, 25kg/drum |
| Minimum Order Quantity (MOQ) |
1 kg (Ready Stock) |
Delivery Lead Time |
Dispatched within 24-48 hours |
| Storage Conditions |
Store in a cool, dark, dry place below 25°C |
Shelf Life (Shelf Life) |
36 Months |
| R&D Sample Support |
Complimentary 30g trial sample available with Franz cell penetration test data |
Quality Documentation |
Batch COA, SDS, TDS, HPLC Purity, Franz Diffusion Cell Reports |
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Product Planning & Marketing Highlights (Marketing Highlights)
Core Mechanism · Efficacy Claims · Recommended Formats · Scientific Backing
🧬 Core Bio-Tech Barrier & Mechanism of Action:
Engineered cyclic peptide topology reversibly modulates stratum corneum lipid packaging, opening temporary 5-minute nano-channels that guide proteins, nucleic acids, and polysaccharides into deep cutaneous strata.
✨ Key Selling Point Keywords:
🏷️ Patented Cyclic Peptide Transdermal Delivery🏷️ Dramatically Enhancing Bio-Absorption🏷️ Deep Hydrating & Nourishing Matrix🏷️ Synergistic Anti-Wrinkle & Firming Boost
🧴 Recommended Product Formats & Categories:
High-potency transdermal booster essences, bio-active ampoules, post-procedure delivery serums, active-infused sheet masks
📜 Patented Technologies & Scientific Backing:
Chinese and US Granted Invention Patents on Cyclic Transdermal Peptide Technology
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Regulatory Compliance & Peer-to-Peer Disclaimer
Regulatory & Professional Compliance Statement:
1. The raw material characteristics and experimental data (including cytological studies, mechanism diagrams, and literature citations) presented on this webpage are intended exclusively for technical discussion and formulation R&D reference by cosmetic brand formulators, R&D engineers, product planners, and academic research institutions. They do not constitute finished consumer cosmetic efficacy claims or commercial warranties.
2. Pursuant to the Regulations on the Supervision and Administration of Cosmetics, Standards for Cosmetic Efficacy Claim Evaluation, and relevant global cosmetic regulatory frameworks, cosmetic brand enterprises utilizing this raw material shall be solely responsible for the safety, stability, and efficacy claims of their finished consumer products, and shall independently complete efficacy evaluations and regulatory filings/registrations with the competent health authorities prior to commercial launch. Conclusions from in-vitro or cellular studies shall not be directly extrapolated as consumer claims.
3. Mellgen Biotech assumes no joint or indirect liability for any claims or regulatory non-compliance arising from improper customer formulation, unauthorized off-label claims, or unverified applications.
